Oral Drug Delivery
Oral Solid Dosage (OSD) Solutions
Dec provides innovative and contained material handling and processing solutions for Oral Solid Dosage (OSD) manufacturing, supporting critical process steps from dispensing to final product processing.
Core Applications
​
-
Bulk Handling: Reliable discharge systems for Intermediate Bulk Containers (IBCs, drums, FIBCs), providing controlled product flow, complete emptying, and ergonomic operation.
-
Powder Transfer: Safe, dust-free transfer of powders and granules between equipment and process stages.
-
Micronization
-
Blending: Efficient blending solutions using contained handling systems and IBC-based processes to ensure consistent product quality.
-
Feeding of Tablet Compression
-
Micronization if required
-
Containment & GMP Compliance: Advanced containment technologies that protect operators, products, and the production environment.
-
Process Efficiency: Seamless integration of various operations to optimize productivity and reduce handling risks.
Orally Disintegrating Tablets (ODT)
The Orally Disintegrating Tablet (ODT) market is experiencing rapid growth, driven by increasing demand for patient-friendly dosage forms. ODTs must disintegrate rapidly, ideally within seconds, to facilitate easy administration, particularly for pediatric, geriatric, and dysphagic patients.
​
Traditional ODT manufacturing technologies often face limitations, including lengthy processing times, restricted drug loading capacities, low API concentration limits, and challenges related to taste masking.
To overcome these constraints, Dec collaborates with the Swiss company Pharmapan in the development and implementation of the innovative Lyopan® technology. Download product sheet
Lyopan® enables significantly higher drug loading, with tablet capacities of up to 750 mg, compared with the typical industry limit of approximately 250 mg. In addition, the technology substantially reduces manufacturing time and costs through an accelerated drying process.
The process involves:
-
Precise dosing of the API directly into blisters using Dec's µPTS (micro Powder Transfer System).
-
Addition of a liquid binder to create the formulation.
-
Freeze-drying of the product to obtain highly porous, fast-disintegrating tablets.
Dec provides a complete, end-to-end powder handling solution for ODT manufacturing, from raw API handling and contained powder transfer to accurate blister filling and freeze-drying integration. For highly potent compounds, fully contained and isolated systems can be implemented to ensure maximum operator protection, product quality, and regulatory compliance.
